SCHEMBL14106949

SCHEMBL14106949

C=C(c1cc(C(C)C)c(O)cc1O)N(C(=O)NN)c1ccc(N2CCC(C)CC2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 11/20 0.38
HSP90AB1 P08238 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
USP2 O75604 1/20 0.37
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
MCL1 Q07820 1/20 0.33
HDAC3 O15379 3/20 0.33
HDAC1 Q13547 3/20 0.33
HDAC8 Q9BY41 3/20 0.33
HDAC6 Q9UBN7 3/20 0.33
HDAC2 Q92769 2/20 0.33
HDAC11 Q96DB2 2/20 0.33
HDAC5 Q9UQL6 2/20 0.33
HDAC7 Q8WUI4 1/20 0.33
HDAC10 Q969S8 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ALDH1A1 P00352 1/20 0.32
MAPT P10636 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14106636 0.91 HSP90AA1 (0.40) HSP90AA1HSP90AB1HDAC3HDAC1HDAC8
SCHEMBL14104704 0.75 HSP90AA1 (0.47) HSP90AA1HSP90AB1
SCHEMBL13833713 0.74 HSP90AA1 (0.42) HSP90AA1HSP90AB1
SCHEMBL14043903 0.73 HSP90AA1 (0.46) HSP90AA1HSP90AB1RAB9AALDH1A1MAPT
SCHEMBL16116988 0.69 HSP90AA1 (0.40) HSP90AA1HSP90AB1
SCHEMBL12634463 0.69 HSP90AA1 (0.49) HSP90AA1HSP90AB1
SCHEMBL19154130 0.67 HSP90AA1 (0.40) HSP90AA1HSP90AB1USP2HDAC3HDAC1
SCHEMBL15000795 0.67 HSP90AA1 (0.68) HSP90AA1HSP90AB1SMN1; SMN2
SCHEMBL21644674 0.66 HSP90AA1 (0.59) HSP90AA1HSP90AB1HDAC3HDAC1HDAC8
SCHEMBL20509051 0.65 HSP90AA1 (0.55) HSP90AA1HSP90AB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008103353-A1 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARMACEUTICALS CORP. (US) 2008-08-28 WO disclosed