Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | GLA | P06280 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | FPR1 | P21462 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14107088 | 0.86 | MEN1 (0.48) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL14107085 | 0.86 | MEN1 (0.48) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4744098 | 0.86 | MEN1 (0.48) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL14107072 | 0.84 | HSD17B10 (0.41) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4291113 | 0.83 | MEN1 (0.49) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4287691 | 0.82 | MEN1 (0.62) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4290980 | 0.81 | MEN1 (0.48) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4296680 | 0.80 | MEN1 (0.47) | MEN1KMT2AHSD17B10ALDH1A1MAPT | |
| SCHEMBL13704059 | 0.80 | MEN1 (0.48) | MEN1KMT2AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL4287067 | 0.79 | MEN1 (0.48) | MEN1KMT2AHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099021-A1 | DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |