Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 16/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 14/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 14/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 13/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 10/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 10/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.55 |
| ▸ | KDM1A | O60341 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MMP1 | P03956 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP9 | P14780 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410846 | 1.00 | HDAC2 (0.64) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL19712547 | 1.00 | HDAC2 (0.64) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1411057 | 1.00 | HDAC2 (0.64) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1411061 | 1.00 | HDAC2 (0.64) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL19712541 | 0.88 | HDAC4 (0.65) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL19712538 | 0.88 | HDAC4 (0.65) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL19712525 | 0.84 | HDAC3 (0.53) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1410952 | 0.84 | HDAC3 (0.53) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL1410951 | 0.84 | HDAC3 (0.53) | HDAC2HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL8243311 | 0.80 | HDAC1 (0.74) | HDAC2HDAC1HDAC8HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |