Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CLK1 | P49759 | 1/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL412384 | 0.78 | CLK4 (0.52) | CLK4NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL19886460 | 0.77 | CLK4 (0.70) | CLK4NPC1RAB9AMAPTLMNA | |
| SCHEMBL21682139 | 0.76 | NPC1 (0.59) | CLK4NPC1RAB9AMAPTLMNA | |
| SCHEMBL2308761 | 0.76 | NPC1 (0.68) | CLK4NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL3669945 | 0.75 | NPC1 (0.63) | CLK4NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL19407789 | 0.75 | CLK4 (0.72) | CLK4NPC1RAB9AMAPTLMNA | |
| SCHEMBL2563374 | 0.75 | CLK4 (0.52) | CLK4NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL27053324 | 0.75 | NPC1 (0.47) | CLK4NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL4300168 | 0.74 | MEN1 (0.56) | CLK4NPC1RAB9AMAPTL3MBTL1 | |
| SCHEMBL20489500 | 0.74 | MAPT (0.57) | CLK4NPC1RAB9AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393851-B2 | Azaindole derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2008-07-01 | — | — | US | disclosed |