Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL1411191 | 0.93 | PDE4B (0.46) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Alpha-Ketoglutaric Acid SCHEMBL1411616 | 0.92 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL14696805 | 0.91 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1411596 | 0.91 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Alpha-Ketoglutaric Acid SCHEMBL1410238 | 0.90 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Hydrochloric Acid SCHEMBL1411219 | 0.90 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Bromide SCHEMBL1411327 | 0.90 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Alpha-Ketoglutaric Acid SCHEMBL1410828 | 0.89 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Fumaric Acid SCHEMBL1411672 | 0.89 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| Fumaric Acid SCHEMBL1411676 | 0.89 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194587-A1 | phosphodiesterase inhibitor; drug for respiratory system disorders | NYCOMED GMBH (DE) | 2008-08-14 | — | — | US | claimed |
| US-8829189-B2 | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives | TAKEDA GMBH (DE) | 2014-09-09 | — | — | US | disclosed |
| US-8754218-B2 | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives | TAKEDA GMBH (DE) | 2014-06-17 | — | — | US | disclosed |
| US-20140039001-A1 | NOVEL SALTS OF 6-HETEROCYCLE SUBSTITUTED HEXAHYDROPHENANTHRIDINE DERIVATIVES | TAKEDA GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| EP-2295423-B1 | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives | TAKEDA GMBH (DE) | 2013-10-02 | — | — | EP | disclosed |
| EP-2189454-B1 | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives | TAKEDA GMBH (DE) | 2013-09-25 | — | — | EP | disclosed |
| US-20130096152-A1 | NOVEL SALTS OF 6-HETEROCYCLE SUBSTITUTED HEXAHYDROPHENANTHRIDINE DERIVATIVES | NYCOMED GMBH (DE) | 2013-04-18 | — | — | US | disclosed |
| US-8354535-B2 | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives | NYCOMED GMBH (DE) | 2013-01-15 | — | — | US | disclosed |
| EP-2295423-A1 | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives | Nycomed GmbH (DE) | 2011-03-16 | — | — | EP | disclosed |
| US-20100190818-A1 | Novel salts of 6-heterocycle substituted hexahydrophenanthridine derivatives | NYCOMED GMBH (DE) | 2010-07-29 | — | — | US | disclosed |
| EP-2189454-A1 | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives | Nycomed GmbH (DE) | 2010-05-26 | — | — | EP | disclosed |
| US-20080194587-A1 | phosphodiesterase inhibitor; drug for respiratory system disorders | NYCOMED GMBH (DE) | 2008-08-14 | — | — | US | disclosed |