Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | LAP3 | P28838 | 1/20 | 0.41 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | NPR3 | P17342 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411042 | 1.00 | ANPEP (0.41) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL1410836 | 0.90 | ANPEP (0.42) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL1410835 | 0.90 | ANPEP (0.42) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL14991225 | 0.86 | MAPK14 (0.44) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL14991224 | 0.86 | MAPK14 (0.44) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL1491354 | 0.85 | HDAC1 (0.49) | LTA4HNPR3HDAC2HDAC8HDAC6 | |
| SCHEMBL1491352 | 0.85 | HDAC1 (0.49) | LTA4HNPR3HDAC2HDAC8HDAC6 | |
| SCHEMBL2281258 | 0.81 | EPHX1 (0.41) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL2281260 | 0.81 | EPHX1 (0.41) | ANPEPMMP2MMP9LTA4HLAP3 | |
| SCHEMBL1410069 | 0.79 | HDAC1 (0.41) | ANPEPMMP2MMP9MMP1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069291-B1 | HDAC INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2017-12-20 | — | — | EP | disclosed |
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |