Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 20/20 | 0.83 |
| ▸ | CCR3 | P51677 | 20/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14110533 | 0.95 | HRH1 (0.87) | HRH1CCR3KCNH2 | |
| SCHEMBL14110637 | 0.94 | HRH1 (0.85) | HRH1CCR3KCNH2 | |
| SCHEMBL14110627 | 0.93 | HRH1 (0.84) | HRH1CCR3KCNH2 | |
| SCHEMBL4208805 | 0.93 | HRH1 (0.85) | HRH1CCR3KCNH2 | |
| SCHEMBL4225035 | 0.91 | HRH1 (0.73) | HRH1CCR3KCNH2 | |
| SCHEMBL18841175 | 0.91 | HRH1 (1.00) | HRH1CCR3KCNH2 | |
| SCHEMBL14110529 | 0.91 | HRH1 (0.85) | HRH1CCR3KCNH2 | |
| Hydrochloric Acid SCHEMBL14110628 | 0.90 | HRH1 (0.98) | HRH1CCR3KCNH2 | |
| SCHEMBL14110564 | 0.88 | HRH1 (0.86) | HRH1CCR3KCNH2 | |
| SCHEMBL18841177 | 0.88 | HRH1 (1.00) | HRH1CCR3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620400-B1 | piperidinylmethylpiperidine derivatives and their use as chemokine modulators | ASTRAZENECA AB (SE) | 2012-12-05 | — | — | EP | disclosed |