Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 14/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 12/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 9/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 9/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411198 | 1.00 | HDAC1 (0.45) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410528 | 0.92 | HDAC1 (0.42) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410517 | 0.92 | HDAC1 (0.42) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410954 | 0.89 | HDAC1 (0.38) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410959 | 0.89 | HDAC1 (0.38) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410830 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410368 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410833 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1410373 | 0.85 | HDAC1 (0.61) | HDAC1HDAC3HDAC8HDAC6HDAC4 | |
| SCHEMBL1411159 | 0.84 | HDAC1 (0.44) | HDAC1HDAC3HDAC8HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295410-A1 | HDAC inhibitor | Chroma Therapeutics Limited (GB) | 2011-03-16 | — | — | EP | disclosed |