Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 13/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.63 |
| ▸ | TUBB | P07437 | 6/20 | 0.63 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.63 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.63 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.63 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.63 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.63 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.63 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.63 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.63 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.63 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.63 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.63 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.63 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.63 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.63 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.63 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fosbretabulin SCHEMBL29374788 | 0.92 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL66079 | 0.92 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL29417596 | 0.92 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL3179235 | 0.91 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL9707816 | 0.91 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL3542758 | 0.91 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Fosbretabulin SCHEMBL9708418 | 0.91 | TUBB1 (0.60) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14175312 | 0.89 | TUBB1 (0.61) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Combretastatin A4 SCHEMBL5073658 | 0.85 | TUBB1 (0.88) | TUBB1TUBB4ATUBBTUBA3CTUBA1B | |
| Phosphoric Acid SCHEMBL5071914 | 0.84 | TUBB1 (0.71) | TUBB1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008103415-A2 | METHODS OF PREPARING PHOSPHORIC ACIDS OF COMBRETASTATIN AND DERIVATIVES THEREOF | OXIGENE, INC. (US) | 2008-08-28 | — | — | WO | disclosed |