Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | FPR2 | P25090 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.31 |
| ▸ | CDK2 | P24941 | 3/20 | 0.31 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2265688 | 0.95 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1410732 | 0.95 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1411548 | 0.91 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1410978 | 0.91 | PDE4D (0.43) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1411280 | 0.88 | PDE4D (0.40) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1411494 | 0.88 | PDE4A (0.42) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1411271 | 0.88 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1411002 | 0.87 | PDE4D (0.41) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL2346530 | 0.87 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL14696083 | 0.86 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003798-B2 | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors | NYCOMED GMBH (DE) | 2011-08-23 | — | — | US | disclosed |
| EP-2295423-A1 | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives | Nycomed GmbH (DE) | 2011-03-16 | — | — | EP | disclosed |