Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 18/20 | 0.67 |
| ▸ | KIT | P10721 | 9/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.47 |
| ▸ | LCK | P06239 | 4/20 | 0.47 |
| ▸ | AXL | P30530 | 4/20 | 0.47 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 2/20 | 0.47 |
| ▸ | STK25 | O00506 | 2/20 | 0.47 |
| ▸ | RIOK3 | O14730 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.47 |
| ▸ | GAK | O14976 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.47 |
| ▸ | MUSK | O15146 | 2/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | MAP3K13 | O43283 | 2/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14117376 | 0.99 | CSF1R (0.68) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL12487348 | 0.91 | CSF1R (0.68) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL14117310 | 0.87 | CSF1R (0.68) | CSF1R | |
| SCHEMBL14117386 | 0.85 | CSF1R (0.56) | CSF1RKITCYP2C19CYP3A4 | |
| SCHEMBL1855955 | 0.85 | CSF1R (0.73) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL1855569 | 0.84 | CSF1R (0.58) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL1855396 | 0.84 | CSF1R (0.59) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL1860908 | 0.84 | CSF1R (0.74) | CSF1RKITCYP2C19NTRK1LCK | |
| SCHEMBL14401644 | 0.80 | CSF1R (0.65) | CSF1RKITCYP2C19NTRK1LCK | |
| Trifluoroacetic Acid SCHEMBL1859712 | 0.80 | CSF1R (0.67) | CSF1RKITCYP2C19NTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414050-B2 | e.g. 4-Cyano-1H-imidazole-2-carboxylic acid [2-cyclohex-1-enyl-4-(2,6-dioxo-piperidin-4-yl)-phenyl]-amide; tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-08-19 | — | — | US | disclosed |