Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 6/20 | 0.33 |
| ▸ | LCK | P06239 | 4/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14119242 | 1.00 | AURKA (0.41) | AURKAAKT1AKT2CCNE2CCNA2 | |
| SCHEMBL14119414 | 1.00 | AURKA (0.41) | AURKAAKT1AKT2CCNE2CCNA2 | |
| SCHEMBL1906235 | 0.91 | AKT1 (0.41) | AURKAAKT1AKT2KITTNK2 | |
| SCHEMBL1904601 | 0.91 | AURKA (0.44) | AURKATNK2LCKJAK2EGFR | |
| SCHEMBL14118738 | 0.90 | AKT1 (0.41) | AURKAAKT1AKT2KITTNK2 | |
| SCHEMBL14120315 | 0.89 | AKT1 (0.43) | AKT1AKT2KITTNK2LCK | |
| SCHEMBL14118996 | 0.88 | AKT1 (0.41) | AURKAAKT1AKT2KITTNK2 | |
| SCHEMBL14120041 | 0.88 | AKT1 (0.41) | AURKAAKT1AKT2CCNE2CCNA2 | |
| SCHEMBL14119016 | 0.88 | AKT1 (0.40) | AURKAAKT1AKT2KITTNK2 | |
| SCHEMBL14120040 | 0.88 | AKT1 (0.41) | AURKAAKT1AKT2CCNE2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309739-A1 | AKT / PKB INHIBITORS | ALMAC DISCOVERY LIMITED (GB) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309739-A1 | AKT / PKB INHIBITORS | AKT1, AKT2, AKT3 | AURKA 527/4885AKT1 1/4885AKT2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.