SCHEMBL14124366

SCHEMBL14124366

Cc1ccccc1NOCc1cc2ccccc2c(N=Nc2ccc3c(c2)C(=O)c2cc(N=Nc4c(O)c(C(=O)Nc5ccccc5Cl)cc5ccccc45)ccc2-3)c1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 5/20 0.40
▸ NPC1 O15118 4/20 0.40
▸ CASP3 P42574 1/20 0.40
▸ ATM Q13315 1/20 0.40
▸ SENP8 Q96LD8 1/20 0.40
▸ SENP7 Q9BQF6 1/20 0.40
▸ SENP6 Q9GZR1 1/20 0.40
▸ NQO2 P16083 1/20 0.40
▸ ALDH1A1 P00352 3/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ F12 P00748 1/20 0.37
▸ MEN1 O00255 6/20 0.36
▸ KMT2A Q03164 6/20 0.36
▸ MAPT P10636 3/20 0.36
▸ KDM4E B2RXH2 3/20 0.36
▸ IDO1 P14902 1/20 0.36
▸ MAPK1 P28482 1/20 0.36
▸ RECQL P46063 1/20 0.36
▸ CASP6 P55212 1/20 0.36
▸ CTDSP1 Q9GZU7 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4407122 0.95 NQO2 (0.42) POLBNPC1CASP3ATMSENP8
SCHEMBL14124267 0.92 NQO2 (0.40) POLBNPC1CASP3ATMSENP8
SCHEMBL14124347 0.92 NPC1 (0.46) POLBNPC1CASP3ATMSENP8
SCHEMBL14124348 0.92 NQO2 (0.46) POLBNPC1CASP3ATMSENP8
SCHEMBL14124260 0.91 NQO2 (0.50) POLBNPC1NQO2ALDH1A1CYP1A2
SCHEMBL12313278 0.91 NQO2 (0.41) POLBNPC1CASP3ATMSENP8
SCHEMBL14124271 0.90 NQO2 (0.41) POLBNPC1CASP3ATMSENP8
SCHEMBL12799096 0.90 NQO2 (0.49) POLBNPC1CASP3ATMSENP8
SCHEMBL14124320 0.89 NPC1 (0.43) POLBNPC1CASP3ATMSENP8
SCHEMBL2741378 0.89 NQO2 (0.42) POLBNPC1CASP3ATMSENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7403735-B2 Image formation apparatus using an electrophotographic process RICOH COMPANY, LTD. (JP) 2008-07-22 — — US disclosed
US-7192677-B2 Electrophotographic photoconductor RICOH COMPANY, LTD. (JP) 2007-03-20 — — US disclosed
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