Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.79 |
| ▸ | PARP1 | P09874 | 12/20 | 0.70 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.56 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 5/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9009947 | 0.91 | KDM4E (0.65) | KDM4EPARP1PARP2HTR1AHTR7 | |
| SCHEMBL12946412 | 0.85 | PARP1 (0.67) | KDM4EPARP1PARP2HTR1AHTR7 | |
| SCHEMBL31060680 | 0.84 | PARP1 (1.00) | PARP1PARP2HTR1AHTR7 | |
| SCHEMBL9009935 | 0.83 | PARP1 (0.65) | KDM4EPARP1PARP2HTR1AHTR7 | |
| SCHEMBL6796265 | 0.79 | PARP1 (0.70) | PARP1PARP2HTR1AHTR7 | |
| SCHEMBL6795921 | 0.77 | PARP1 (0.70) | PARP1PARP2HTR1AHTR7 | |
| SCHEMBL30111044 | 0.76 | PARP1 (0.83) | PARP1PARP2HTR1AHTR7 | |
| SCHEMBL6795915 | 0.73 | PARP1 (0.70) | PARP1PARP2HTR1AHTR7 | |
| SCHEMBL14981676 | 0.72 | PARP1 (1.00) | PARP1PARP2HTR1AHTR7 | |
| SCHEMBL9070730 | 0.72 | PARP1 (0.65) | PARP1PARP2HTR1AHTR7SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176876-A1 | Poly(ADP-ribose)polymerase (PARP); ischemia, reperfusion injuries, neurological disorders, neuroprotectants, sensitizer for chemotherapy or radiotherapy, anticancer | JANSSEN PHARMACEUTICA, NV (BE) | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176876-A1 | Poly(ADP-ribose)polymerase (PARP); ischemia, reperfusion injuries, neurological disorders, neuroprotectants, sensitizer for chemotherapy or radiotherapy, anticancer | PARP1, PARP2, PARP3 | KDM4E 3137/4885PARP1 1/4885PARP2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.