Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 19/20 | 0.67 |
| ▸ | F10 | P00742 | 2/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14131773 | 0.94 | F2 (0.69) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5122843 | 0.90 | F2 (0.70) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL5753312 | 0.89 | F2 (0.72) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5116789 | 0.89 | F2 (0.71) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL5755835 | 0.88 | F2 (0.78) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL5756218 | 0.88 | F2 (0.68) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5851676 | 0.88 | F2 (0.77) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5123399 | 0.87 | F2 (0.67) | F2F10PRSS1PRSS2PRSS3 | |
| Hydrochloric Acid SCHEMBL5118015 | 0.85 | F2 (0.66) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL14131865 | 0.85 | F2 (0.61) | F2F10PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402586-B2 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-07-22 | — | — | US | disclosed |
| US-7402586-B2 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-07-22 | — | — | US | disclosed |