Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.63 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.55 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1413409 | 0.88 | CRBN (0.63) | CRBNCSNK1A1GSPT1 | |
| SCHEMBL1413692 | 0.87 | CRBN (0.62) | CRBNCSNK1A1GSPT1IKZF2 | |
| SCHEMBL1413446 | 0.87 | CRBN (0.62) | CRBNCSNK1A1GSPT1IKZF2 | |
| SCHEMBL1413715 | 0.87 | CRBN (0.62) | CRBNCSNK1A1GSPT1 | |
| SCHEMBL1413587 | 0.86 | CRBN (0.61) | CRBNCSNK1A1GSPT1 | |
| SCHEMBL1413615 | 0.85 | CRBN (0.60) | CRBNCSNK1A1GSPT1 | |
| SCHEMBL1413504 | 0.84 | CRBN (0.59) | CRBNCSNK1A1GSPT1IKZF2 | |
| SCHEMBL4448246 | 0.84 | CRBN (0.59) | CRBNCSNK1A1GSPT1 | |
| SCHEMBL1413390 | 0.84 | CRBN (0.59) | CRBNCSNK1A1GSPT1IKZF2 | |
| SCHEMBL30042984 | 0.84 | CRBN (0.72) | CRBNCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291365-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2011-03-09 | — | — | EP | disclosed |