Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 4/20 | 0.42 |
| ▸ | CCND1 | P24385 | 4/20 | 0.42 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.42 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.42 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 2/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997812 | 0.88 | MAPK14 (0.53) | CDK4CCND1CDK1CCNB1CDK2 | |
| SCHEMBL4998381 | 0.84 | CDK2 (0.52) | CDK4CCND1CDK1CCNA2CDK2 | |
| SCHEMBL5001985 | 0.77 | CDK2 (0.50) | CDK4CCND1CDK1CCNB1CCNA2 | |
| SCHEMBL5001992 | 0.74 | CDK2 (0.51) | CDK4CCND1CDK1CCNB1CDK2 | |
| SCHEMBL5049489 | 0.73 | CDK2 (0.49) | AXLCDK4CCND1CDK1CCNB1 | |
| SCHEMBL5001638 | 0.73 | CDK2 (0.55) | DYRK1ACDK4CCND1CDK1CCNB1 | |
| SCHEMBL4997884 | 0.71 | BTK (0.43) | DYRK1ACDK2MAPK1KDM4EALDH1A1 | |
| SCHEMBL5001905 | 0.71 | CDK1 (0.58) | DYRK1ACDK4CCND1CDK1CCNB1 | |
| SCHEMBL5812100 | 0.71 | KCNH2 (0.55) | MAPK8MAPK9 | |
| SCHEMBL5817294 | 0.69 | KCNH2 (0.53) | MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405220-B2 | Pyrazolopyrimidines | HOFFMANN-LA ROCHE INC. (US) | 2008-07-29 | — | — | US | disclosed |