Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 5/20 | 0.37 |
| ▸ | METAP2 | P50579 | 3/20 | 0.31 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.31 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4154953 | 1.00 | TLR4 (0.37) | TLR4METAP2MRGPRX1TSPONPC1 | |
| SCHEMBL15093757 | 1.00 | TLR4 (0.37) | TLR4METAP2MRGPRX1TSPONPC1 | |
| SCHEMBL4163042 | 1.00 | TLR4 (0.37) | TLR4METAP2MRGPRX1TSPONPC1 | |
| SCHEMBL4153932 | 0.91 | TLR4 (0.38) | TLR4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17727702 | 0.91 | TLR4 (0.38) | TLR4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4145794 | 0.91 | TLR4 (0.38) | TLR4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17727727 | 0.89 | TLR4 (0.49) | TLR4MRGPRX1NPC1PKMRAB9A | |
| SCHEMBL14136690 | 0.89 | TLR4 (0.49) | TLR4MRGPRX1NPC1PKMRAB9A | |
| SCHEMBL4141115 | 0.89 | TLR4 (0.49) | TLR4MRGPRX1NPC1PKMRAB9A | |
| SCHEMBL4146514 | 0.89 | TLR4 (0.49) | TLR4MRGPRX1NPC1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935879-B1 | SUBSTITUTED CYCLOALKENE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2016-05-11 | — | — | EP | claimed |
| US-RE43858-E1 | Substituted cycloalkene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-12-11 | — | — | US | claimed |