Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 11/20 | 0.40 |
| ▸ | RAF1 | P04049 | 9/20 | 0.40 |
| ▸ | CSF1R | P07333 | 6/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 5/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ARAF | P10398 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14125143 | 0.96 | BRAF (0.39) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2236303 | 0.88 | NPC1 (0.43) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL14125057 | 0.86 | NPC1 (0.42) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2232145 | 0.85 | BRAF (0.45) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2234259 | 0.84 | BRAF (0.46) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2297740 | 0.84 | BRAF (0.38) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2233292 | 0.83 | BRAF (0.46) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2233941 | 0.82 | LCK (0.47) | NPC1RAB9ALCKKDM4E | |
| SCHEMBL14125127 | 0.81 | BRAF (0.45) | BRAFRAF1CSF1RDDR1DDR2 | |
| SCHEMBL2235183 | 0.81 | BRAF (0.42) | BRAFRAF1CSF1RDDR1DDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302567-A1 | BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2012-11-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302567-A1 | BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE | CDK2, SBK3, CDK2AP1 | BRAF 113/4885RAF1 130/4885CSF1R 4274/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.