Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 14/20 | 0.71 |
| ▸ | GSPT1 | P15170 | 4/20 | 0.71 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.71 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 8/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | IKZF2 | Q9UKS7 | 12/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL60743 | 0.89 | CRBN (0.67) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL29285298 | 0.86 | CRBN (0.79) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL1413754 | 0.86 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL4461692 | 0.86 | CRBN (0.71) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL68744 | 0.85 | CRBN (0.74) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL28881329 | 0.84 | CRBN (0.73) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL28881292 | 0.84 | CRBN (0.73) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL60871 | 0.84 | CRBN (0.76) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL1413700 | 0.84 | CRBN (0.86) | CRBNGSPT1DDB1IKZF3CSNK1A1 | |
| SCHEMBL1403564 | 0.84 | CRBN (0.86) | CRBNGSPT1DDB1IKZF3CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291365-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009145899-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2009-12-03 | — | — | WO | disclosed |