Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 20/20 | 0.68 |
| ▸ | RAF1 | P04049 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596800 | 0.81 | BRAF (0.79) | BRAFRAF1 | |
| SCHEMBL3588734 | 0.81 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3594312 | 0.81 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3594975 | 0.79 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3597307 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3588859 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3593714 | 0.77 | BRAF (0.82) | BRAFRAF1 | |
| SCHEMBL3597324 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3593181 | 0.77 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL3589127 | 0.75 | BRAF (0.82) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |