Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 18/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3595706 | 0.90 | BRAF (0.72) | BRAF | |
| SCHEMBL3598887 | 0.79 | BRAF (0.73) | BRAFMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL3597006 | 0.79 | BRAF (0.68) | BRAF | |
| SCHEMBL3602586 | 0.78 | BRAF (0.69) | BRAF | |
| SCHEMBL3588107 | 0.77 | BRAF (0.69) | BRAF | |
| SCHEMBL3594450 | 0.76 | BRAF (0.68) | BRAF | |
| SCHEMBL3601753 | 0.76 | BRAF (0.80) | BRAF | |
| SCHEMBL3587726 | 0.74 | BRAF (1.00) | BRAF | |
| SCHEMBL3593499 | 0.74 | BRAF (0.73) | BRAF | |
| SCHEMBL3594998 | 0.74 | BRAF (0.70) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008079277-A1 | CERTAIN PYRAZOLINE DERIVATIVES WITH KINASE INHIBITORY ACTIVITY | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-07-03 | — | — | WO | disclosed |