Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 16/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.38 |
| ▸ | EHMT1 | Q9H9B1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995771 | 0.85 | PIK3CB (0.57) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL951445 | 0.76 | PIK3CA (0.60) | PIK3CBPIK3CDPIK3CAPIK3R1 | |
| SCHEMBL948190 | 0.72 | PIK3CB (0.64) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL949368 | 0.70 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL950709 | 0.70 | PIK3CB (0.62) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL15009649 | 0.69 | PIK3CB (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL947217 | 0.69 | PIK3CB (0.58) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL949292 | 0.68 | PIK3CB (0.57) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL949282 | 0.68 | PIK3CB (0.58) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL947460 | 0.67 | PIK3CB (0.70) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532659-A1 | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy | Pathway Therapeutics, Inc. (US) | 2012-12-12 | — | — | EP | disclosed |