Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 8/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5874340 | 0.85 | TOP2A (0.53) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL13581390 | 0.82 | TOP2A (0.51) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL9088413 | 0.79 | TOP2A (0.48) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL14143514 | 0.79 | DPP4 (0.54) | TOP2ATOP2BKCNH2KDM4EALDH1A1 | |
| SCHEMBL9090016 | 0.78 | KCNH2 (0.54) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL14143513 | 0.77 | GSK3B (0.55) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL14143617 | 0.77 | KCNH2 (0.63) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL10440717 | 0.77 | PIM3 (0.51) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| Hydrochloric Acid SCHEMBL10440761 | 0.77 | KCNH2 (0.53) | TOP2ATOP2BKCNH2HRH3MEN1 | |
| SCHEMBL9088107 | 0.77 | PIM3 (0.65) | TOP2ATOP2BKCNH2HRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393957-B2 | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments | WOCKHARDT LIMITED (IN) | 2008-07-01 | — | — | US | disclosed |