Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
| ▸ | PI4KA | P42356 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 10/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14145116 | 0.86 | ATM (0.63) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL14145557 | 0.77 | ATM (0.53) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL27334083 | 0.77 | ATM (1.00) | ATMMKNK1MKNK2FYN | |
| SCHEMBL14145882 | 0.75 | ATM (0.51) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL14373184 | 0.74 | FYN (0.55) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL25149703 | 0.73 | ATM (0.51) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL3850100 | 0.71 | PIK3CA (0.53) | ATMMKNK1MKNK2FYNCYP3A4 | |
| SCHEMBL3025915 | 0.71 | MKNK1 (0.54) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL15717468 | 0.71 | PIK3CD (0.69) | ATMPIK3CDPIK3CBPI4KAPIK3CG | |
| SCHEMBL15718930 | 0.71 | PIK3CD (0.59) | ATMPIK3CDPIK3CBPI4KAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1382603-B1 | NITROGENOUS FUSED-RING COMPOUND HAVING PYRAZOLYL GROUP AS SUBSTITUENT AND MEDICINAL COMPOSITION THEREOF | EISAI R&D MAN CO LTD (JP) | 2008-07-23 | — | — | EP | disclosed |