Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 20/20 | 0.59 |
| ▸ | PRSS1 | P07477 | 12/20 | 0.59 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5112954 | 0.81 | F2 (0.63) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL8367165 | 0.79 | F2 (0.63) | F2PRSS1 | |
| SCHEMBL4420702 | 0.77 | F2 (0.62) | F2PRSS1 | |
| Trifluoroacetic Acid SCHEMBL5124661 | 0.75 | F2 (0.69) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL5753662 | 0.74 | F2 (0.64) | F2PRSS1F10 | |
| SCHEMBL3244661 | 0.74 | F2 (0.69) | F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5757596 | 0.74 | F2 (0.69) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL5754201 | 0.74 | F2 (0.65) | F2PRSS1PRSS2PRSS3F10 | |
| SCHEMBL14145225 | 0.74 | ELANE (0.60) | F2PRSS1 | |
| SCHEMBL4422918 | 0.72 | F2 (0.56) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7402586-B2 | Heteroaryl aminoguanidines and alkoxyguanidines and their use as protease inhibitors | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2008-07-22 | — | — | US | disclosed |