Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.70 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.70 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.70 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14533000 | 0.88 | ADORA2A (0.56) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL13296396 | 0.88 | ADORA2A (0.66) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL3425443 | 0.88 | ADORA2A (0.66) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL13314261 | 0.88 | ADORA2A (0.66) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL14532884 | 0.87 | ADORA2A (0.61) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL14148777 | 0.86 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5411319 | 0.85 | ADORA2A (0.81) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL5416149 | 0.84 | ADORA2A (0.80) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL13385561 | 0.84 | ADORA2A (0.65) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL14532795 | 0.84 | ADORA2A (0.65) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7396825-B2 | Agonists of A2A adenosine receptors for treatment of diabetic nephropathy | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2008-07-08 | — | — | US | disclosed |