Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 11/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 8/20 | 0.45 |
| ▸ | ABL1 | P00519 | 7/20 | 0.45 |
| ▸ | BCR | P11274 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 4/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1408559 | 0.92 | KCNJ5 (0.41) | RETKDR | |
| SCHEMBL1408518 | 0.91 | MKNK2 (0.52) | MKNK2MKNK1ABL1BCRCYP3A4 | |
| SCHEMBL4718201 | 0.88 | ABL1 (0.41) | ABL1RETKDRKITSRC | |
| SCHEMBL1408285 | 0.86 | SRC (0.53) | ABL1RETKITSRC | |
| SCHEMBL2203870 | 0.85 | ABL1 (0.44) | MKNK2MKNK1ABL1BCRRET | |
| SCHEMBL1408098 | 0.84 | ABL1 (0.44) | MKNK2MKNK1ABL1BCRRET | |
| SCHEMBL1414442 | 0.84 | MKNK2 (0.53) | MKNK2MKNK1ABL1BCRCYP3A4 | |
| SCHEMBL1407966 | 0.82 | MKNK2 (0.63) | MKNK2MKNK1ABL1BCRCYP3A4 | |
| SCHEMBL2202884 | 0.82 | MKNK2 (0.42) | MKNK2MKNK1ABL1BCRRET | |
| SCHEMBL2199413 | 0.81 | KCNJ5 (0.44) | MKNK2MKNK1ABL1BCRRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874770-B1 | PHENYLACETAMIDES SUITABLE AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-09 | — | — | EP | claimed |