Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.82 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.82 |
| ▸ | HDAC4 | P56524 | 16/20 | 0.82 |
| ▸ | HDAC7 | Q8WUI4 | 16/20 | 0.82 |
| ▸ | HDAC2 | Q92769 | 16/20 | 0.82 |
| ▸ | HDAC10 | Q969S8 | 16/20 | 0.82 |
| ▸ | HDAC11 | Q96DB2 | 16/20 | 0.82 |
| ▸ | HDAC8 | Q9BY41 | 16/20 | 0.82 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.82 |
| ▸ | HDAC9 | Q9UKV0 | 16/20 | 0.82 |
| ▸ | HDAC5 | Q9UQL6 | 16/20 | 0.82 |
| ▸ | GCK | P35557 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377817 | 0.90 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1377819 | 0.90 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1374007 | 0.90 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1374010 | 0.90 | HDAC1 (1.00) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL14159463 | 0.89 | HDAC1 (0.81) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL12431862 | 0.89 | HDAC1 (0.81) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1377260 | 0.88 | HDAC1 (0.85) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1377257 | 0.88 | HDAC1 (0.85) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1374019 | 0.87 | HDAC1 (0.87) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1374015 | 0.87 | HDAC1 (0.87) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492534-B1 | CARBAMIC ACID COMPOUNDS COMPRISING A PIPERAZINE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LTD (GB) | 2008-06-25 | — | — | EP | disclosed |