Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | FASN | P49327 | 13/20 | 0.41 |
| ▸ | RBP4 | P02753 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197824 | 0.87 | CYP3A4 (0.57) | CYP3A4CYP2C9SLC9A1CYP2C19KCNH2 | |
| SCHEMBL14161527 | 0.86 | FASN (0.42) | FASN | |
| SCHEMBL14210045 | 0.85 | FASN (0.40) | CYP3A4CYP2C9SLC9A1CYP2C19KCNH2 | |
| SCHEMBL14161783 | 0.84 | FASN (0.43) | FASN | |
| SCHEMBL14161578 | 0.84 | FASN (0.47) | FASN | |
| SCHEMBL14161690 | 0.83 | FASN (0.48) | FASN | |
| SCHEMBL14161764 | 0.81 | FASN (0.45) | FASN | |
| SCHEMBL14209856 | 0.81 | FASN (0.48) | FASN | |
| SCHEMBL14161756 | 0.80 | FASN (0.52) | FASN | |
| SCHEMBL14161790 | 0.79 | FASN (0.48) | FASN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075064-A1 | PIPERIDINE DERIVATIVES FOR THE TREATMENT OF OBESITY | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008059214-A1 | BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-05-22 | — | — | WO | disclosed |