Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.59 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1384534 | 0.91 | MAPK14 (0.63) | MAPK14MAPK11CYP3A4CYP2C9 | |
| SCHEMBL1416903 | 0.89 | MAPK14 (0.54) | MAPK14MAPK11CYP3A4CYP2C9 | |
| SCHEMBL1417047 | 0.88 | MAPK14 (0.73) | MAPK14MAPK11 | |
| SCHEMBL5439845 | 0.86 | MAPK14 (0.67) | MAPK14MAPK11CYP2C9 | |
| SCHEMBL1383736 | 0.86 | MAPK14 (0.66) | MAPK14MAPK11 | |
| Pivalamide SCHEMBL1417083 | 0.85 | MAPK14 (0.58) | MAPK14MAPK11CYP3A4CYP2C9 | |
| SCHEMBL1386388 | 0.85 | MAPK14 (0.66) | MAPK14MAPK11CYP3A4CYP2C9 | |
| SCHEMBL1417085 | 0.84 | MAPK14 (0.57) | MAPK14MAPK11CYP3A4CYP2C9 | |
| SCHEMBL1416991 | 0.83 | MAPK14 (0.60) | MAPK14MAPK11CYP3A4CYP2C9 | |
| SCHEMBL1417156 | 0.83 | MAPK14 (0.70) | MAPK14MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298743-A1 | 5-membered heterocycle-based P38 kinase inhibitors | Novartis AG (CH) | 2011-03-23 | — | — | EP | claimed |