Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.76 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.75 |
| ▸ | ERBB4 | Q15303 | 6/20 | 0.75 |
| ▸ | JAK3 | P52333 | 2/20 | 0.75 |
| ▸ | GAK | O14976 | 1/20 | 0.67 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.67 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | DRD2 | P14416 | 1/20 | 0.67 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | MC3R | P41968 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.67 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1417893 | 1.00 | EGFR (0.76) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1417903 | 0.94 | EGFR (0.65) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1417904 | 0.94 | EGFR (0.65) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL6495901 | 0.92 | EGFR (0.73) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL6495898 | 0.92 | EGFR (0.73) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1418219 | 0.91 | EGFR (0.63) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1418217 | 0.91 | EGFR (0.63) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1418794 | 0.90 | EGFR (0.61) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL1418793 | 0.90 | EGFR (0.61) | EGFRERBB2ERBB4JAK3GAK | |
| SCHEMBL867639 | 0.90 | EGFR (0.85) | EGFRERBB2ERBB4JAK3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |