Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4821303 | 0.92 | PDGFRB (0.53) | PDGFRBPDGFRAFLT3HRH3HRH4 | |
| SCHEMBL4818482 | 0.92 | PDGFRB (0.53) | PDGFRBPDGFRAFLT3HRH3HRH4 | |
| Hydrochloric Acid SCHEMBL4815345 | 0.91 | PDGFRB (0.52) | PDGFRBPDGFRAFLT3HRH3HRH4 | |
| SCHEMBL14613774 | 0.90 | PDGFRB (0.52) | PDGFRBPDGFRAFLT3HRH3HRH4 | |
| SCHEMBL14178952 | 0.90 | KDM4E (0.46) | PDGFRBPDGFRAFLT3KDM4EALDH1A1 | |
| SCHEMBL4250060 | 0.90 | PDGFRB (0.51) | PDGFRBPDGFRAFLT3HRH3HRH4 | |
| SCHEMBL8312368 | 0.81 | HDAC1 (0.46) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL14613790 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL15223791 | 0.79 | PDGFRB (0.74) | PDGFRBPDGFRAFLT3HRH3HRH4 | |
| SCHEMBL4819051 | 0.77 | KDM4E (0.56) | PDGFRBPDGFRAKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368572-B2 | Acetylene derivatives as inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2008-05-06 | — | — | US | disclosed |