Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | GSTP1 | P09211 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17821298 | 1.00 | PDPK1 (0.42) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL3859887 | 1.00 | PDPK1 (0.42) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL13683691 | 1.00 | PDPK1 (0.42) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL3856126 | 1.00 | PDPK1 (0.42) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL3867701 | 1.00 | PDPK1 (0.42) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL17827490 | 1.00 | PDPK1 (0.42) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL7833562 | 0.93 | PDPK1 (0.41) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL14180112 | 0.92 | PDPK1 (0.43) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL8690255 | 0.90 | PDPK1 (0.41) | PDPK1MTORIDO1BCHEMEN1 | |
| SCHEMBL14180110 | 0.90 | PDPK1 (0.41) | PDPK1MTORIDO1BCHEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378403-B2 | Akt inhibitors, pharmaceutical compositions, and uses thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-05-27 | — | — | US | disclosed |