Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 11/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418675 | 0.96 | EGFR (0.76) | EGFRERBB2KDR | |
| SCHEMBL1418198 | 0.96 | EGFR (0.80) | EGFRERBB2KDR | |
| SCHEMBL1417998 | 0.89 | EGFR (0.73) | EGFRERBB2KDR | |
| SCHEMBL4230930 | 0.89 | EGFR (0.67) | EGFRERBB2KDR | |
| SCHEMBL1417983 | 0.88 | EGFR (0.63) | EGFRERBB2KDR | |
| SCHEMBL1417985 | 0.88 | EGFR (0.63) | EGFRERBB2KDR | |
| SCHEMBL1418733 | 0.86 | EGFR (0.76) | EGFRERBB2KDR | |
| SCHEMBL2987786 | 0.86 | EGFR (1.00) | EGFRERBB2KDR | |
| SCHEMBL4232040 | 0.86 | KDR (0.67) | EGFRERBB2KDR | |
| SCHEMBL1418926 | 0.86 | EGFR (0.59) | EGFRERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |
| EP-1157011-A1 | 4-AMINO- QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANSDUCTION MEDIATED BY TYROSINE KINASES | Boehringer Ingelheim Pharma KG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2000051991-A1 | 4-AMINO-QUINAZOLINE AND QUINOLINE DERIVATIVES HAVING AN INHIBITORY EFFECT ON SIGNAL TRANsSDUCTION MEDIATED BY TYROSINE KINASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-09-08 | — | — | WO | disclosed |