Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 17/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.52 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.52 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | MARK3 | P27448 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.49 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1843851 | 1.00 | S1PR1 (0.73) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL1841883 | 0.92 | S1PR1 (0.72) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL400101 | 0.91 | S1PR1 (0.78) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL403510 | 0.91 | S1PR1 (0.78) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL10130558 | 0.85 | S1PR1 (0.75) | S1PR1MAP4K4MINK1S1PR3PRKCD | |
| SCHEMBL398987 | 0.84 | S1PR1 (1.00) | S1PR1MAP4K4MINK1S1PR3S1PR5 | |
| SCHEMBL403328 | 0.84 | S1PR1 (0.78) | S1PR1MAP4K4MINK1S1PR3DYRK3 | |
| SCHEMBL401604 | 0.84 | S1PR1 (0.92) | S1PR1MAP4K4MINK1S1PR3S1PR5 | |
| SCHEMBL404571 | 0.83 | S1PR1 (0.81) | S1PR1MAP4K4MINK1S1PR3PRKCD | |
| SCHEMBL403591 | 0.83 | S1PR1 (0.90) | S1PR1MAP4K4MINK1S1PR3S1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008074821-A1 | INDOLE DERIVATIVES AS S1P1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |