Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.63 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418997 | 1.00 | EGFR (0.65) | EGFRERBB2JAK3ERBB4KDM4E | |
| SCHEMBL1418061 | 0.95 | EGFR (0.62) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1418063 | 0.95 | EGFR (0.62) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1418182 | 0.94 | EGFR (0.62) | EGFRERBB2JAK3ERBB4KDR | |
| SCHEMBL1418183 | 0.94 | EGFR (0.62) | EGFRERBB2JAK3ERBB4KDR | |
| SCHEMBL1418259 | 0.93 | EGFR (0.60) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1417866 | 0.93 | EGFR (0.60) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1417867 | 0.93 | EGFR (0.60) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1418260 | 0.93 | EGFR (0.60) | EGFRERBB2JAK3ERBB4 | |
| SCHEMBL1418886 | 0.92 | EGFR (0.61) | EGFRERBB2JAK3ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |