Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AIMP2 | Q13155 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 4/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224087 | 0.94 | AIMP2 (0.42) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14195969 | 0.92 | GSK3B (0.45) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224273 | 0.92 | AIMP2 (0.45) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224075 | 0.91 | AIMP2 (0.48) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14195988 | 0.88 | AIMP2 (0.42) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224074 | 0.88 | AIMP2 (0.44) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224359 | 0.87 | AIMP2 (0.48) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224454 | 0.86 | AIMP2 (0.47) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224453 | 0.86 | SYK (0.41) | AIMP2SYKEGFRABL1BCR | |
| SCHEMBL14224140 | 0.86 | AIMP2 (0.50) | AIMP2SYKEGFRABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |