Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 11/20 | 0.56 |
| ▸ | BCR | P11274 | 10/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | PRKCA | P17252 | 2/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.56 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.50 |
| ▸ | ABL2 | P42684 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | PRKACG | P22612 | 1/20 | 0.43 |
| ▸ | PRKACB | P22694 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14196025 | 0.94 | ABL1 (0.54) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14195960 | 0.93 | ABL1 (0.53) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14196020 | 0.93 | ABL1 (0.59) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14195957 | 0.91 | ABL1 (0.52) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14224358 | 0.91 | AIMP2 (0.49) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14195977 | 0.90 | AIMP2 (0.51) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14195958 | 0.90 | ABL1 (0.51) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14195994 | 0.90 | AIMP2 (0.49) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14224075 | 0.90 | AIMP2 (0.48) | ABL1BCREGFRSRCPRKCA | |
| SCHEMBL14195964 | 0.86 | ABL1 (0.56) | ABL1BCREGFRSRCPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |
| US-7361665-B2 | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-22 | — | — | US | disclosed |