Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | VNN1 | O95497 | 4/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12304412 | 0.91 | CYP3A4 (0.59) | CSF1RCYP3A4CYP1A2HDAC1CYP2C19 | |
| SCHEMBL4503728 | 0.81 | CYP2C9 (0.60) | CSF1RCYP3A4CYP1A2CYP2C19VNN1 | |
| SCHEMBL2113102 | 0.77 | CYP3A4 (0.48) | CSF1RCYP3A4HDAC1CYP2C19VNN1 | |
| SCHEMBL15987210 | 0.74 | CSF1R (0.71) | CSF1RCYP3A4CYP1A2CYP2C19VNN1 | |
| SCHEMBL1267969 | 0.73 | CYP3A4 (0.76) | CSF1RCYP3A4CYP1A2CYP2C19AAK1 | |
| SCHEMBL1890622 | 0.72 | CYP3A4 (0.76) | CSF1RCYP3A4CYP1A2CYP2C19AAK1 | |
| SCHEMBL1267844 | 0.71 | CSF1R (0.77) | CSF1RCYP3A4CYP1A2CYP2C19AAK1 | |
| SCHEMBL1885108 | 0.70 | CSF1R (0.81) | CSF1RCYP3A4CYP1A2CYP2C19AAK1 | |
| SCHEMBL15987202 | 0.70 | KIT (0.55) | CSF1RCYP3A4CYP2C19VNN1AAK1 | |
| SCHEMBL1267898 | 0.70 | ADORA2A (0.55) | CSF1RVNN1LCKKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |