Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 17/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1266685 | 0.73 | CYP1A2 (0.67) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL1267479 | 0.73 | CYP3A4 (0.80) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL14196176 | 0.73 | CYP2C19 (0.44) | CYP3A4CYP2C9CYP2C19KITKDR | |
| SCHEMBL2112330 | 0.72 | CYP1A2 (0.69) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL1882053 | 0.71 | CYP3A4 (0.82) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL1267946 | 0.70 | CYP3A4 (0.50) | CYP3A4CYP1A2CYP2C9 | |
| SCHEMBL1887500 | 0.69 | CYP3A4 (1.00) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL12899423 | 0.69 | CYP1A2 (0.73) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL1266480 | 0.69 | CYP1A2 (0.71) | CYP3A4CYP1A2CYP2C9CYP2C19KIT | |
| SCHEMBL1888289 | 0.69 | CYP1A2 (1.00) | CYP3A4CYP1A2CYP2C9CYP2C19KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |