Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | FPR3 | P25089 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | IL1B | P01584 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1237986 | 0.86 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL2486249 | 0.83 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL5847543 | 0.83 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL18872558 | 0.83 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL4169505 | 0.83 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL3249457 | 0.83 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL24335833 | 0.82 | KDM1A (0.47) | SMN1; SMN2OPRD1FPR3FPR2KDM1A | |
| SCHEMBL27353410 | 0.82 | KDM1A (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL27353429 | 0.82 | KDM1A (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 | |
| SCHEMBL27353413 | 0.82 | KDM1A (0.47) | KMT2ASMN1; SMN2OPRD1FPR3FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7354946-B2 | prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-08 | — | — | US | disclosed |
| US-7354946-B2 | prominent growth inhibitory activity against tumor cells; cyclin dependent kinase inhibitors; colon cancer; N'-(3-t-butylisoindolino[3,2-b]oxazolidin-4-on-8-yl)-N-(4-(N-benzylpyrrolidin-3-yl)pyridin-2-yl)urea | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-08 | — | — | US | disclosed |