Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20605747 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL13551047 | 0.81 | SMN1; SMN2 (0.69) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL12654050 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL12828972 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2CXCR4HTTNPC1RAB9A | |
| SCHEMBL307293 | 0.80 | SMN1; SMN2 (1.00) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| Hydrochloric Acid SCHEMBL3606873 | 0.79 | SMN1; SMN2 (0.97) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL24160695 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL2250240 | 0.78 | SMN1; SMN2 (0.63) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL12669618 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2CXCR4HTTDRD2DRD4 | |
| SCHEMBL12028984 | 0.76 | SMN1; SMN2 (0.61) | SMN1; SMN2CXCR4HTTDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297144-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009146358-A1 | IMIDAZOPYRIDINE AND RELATED ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | WO | disclosed |