Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.79 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.71 |
| ▸ | FYN | P06241 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | BLK | P51451 | 1/20 | 0.62 |
| ▸ | BMX | P51813 | 1/20 | 0.62 |
| ▸ | JAK3 | P52333 | 1/20 | 0.62 |
| ▸ | BTK | Q06187 | 1/20 | 0.62 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1420005 | 1.00 | EGFR (0.79) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2990560 | 0.88 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL7208199 | 0.88 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2986126 | 0.82 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL6586413 | 0.81 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL1417861 | 0.81 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL1417862 | 0.81 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2988658 | 0.81 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2988661 | 0.81 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL2994192 | 0.81 | EGFR (0.86) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2298746-A1 | 4-amino- quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |