Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 16/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4699924 | 0.85 | GRM5 (0.64) | GRM5 | |
| SCHEMBL4704660 | 0.82 | GRM5 (0.66) | GRM5 | |
| SCHEMBL4701864 | 0.81 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4701778 | 0.81 | GRM5 (0.67) | GRM5 | |
| SCHEMBL4701486 | 0.81 | NPC1 (0.67) | GRM5 | |
| SCHEMBL4699251 | 0.81 | GRM5 (0.76) | GRM5 | |
| SCHEMBL4699775 | 0.80 | GRM5 (0.63) | GRM5 | |
| SCHEMBL13684009 | 0.80 | GRM5 (1.00) | GRM5 | |
| SCHEMBL3372897 | 0.80 | GRM5 (0.66) | GRM5 | |
| SCHEMBL13068986 | 0.79 | GRM5 (0.81) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434773-B1 | HETEROARYL SUBSTITUTED TETRAZOLE MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5 | MERCK & CO INC (US) | 2008-05-21 | — | — | EP | disclosed |