Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 11/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922999 | 0.88 | P2RY12 (0.55) | P2RY12KITFBP1MAPTMEN1 | |
| SCHEMBL13635285 | 0.87 | P2RY12 (0.63) | P2RY12MAPTMEN1KMT2ATP53 | |
| SCHEMBL12161688 | 0.86 | P2RY12 (0.48) | P2RY12KITMAPTMEN1KMT2A | |
| SCHEMBL9923004 | 0.86 | P2RY12 (0.52) | P2RY12KITFBP1MAPTMEN1 | |
| SCHEMBL9922414 | 0.85 | P2RY12 (0.58) | P2RY12KITMAPTMEN1KMT2A | |
| SCHEMBL9922412 | 0.84 | P2RY12 (0.54) | P2RY12MAPTMEN1KMT2AERCC1 | |
| SCHEMBL9922413 | 0.84 | P2RY12 (0.59) | P2RY12MAPTMEN1KMT2ATP53 | |
| SCHEMBL9923007 | 0.83 | P2RY12 (0.54) | P2RY12KITFBP1MAPTMEN1 | |
| SCHEMBL12161684 | 0.83 | P2RY12 (0.56) | P2RY12MAPTMEN1KMT2AERCC1 | |
| SCHEMBL9922330 | 0.83 | P2RY12 (0.62) | P2RY12KITFBP1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |
| US-7358257-B2 | sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives; effective for prevention and treatment of cardiovascular diseases, antithrombotic agents | PORTOLA PHARMACEUTICALS, INC. (US) | 2008-04-15 | — | — | US | disclosed |