Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14201065 | 0.96 | SMN1; SMN2 (0.52) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201095 | 0.94 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201139 | 0.93 | HPGD (0.52) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201086 | 0.92 | SMN1; SMN2 (0.49) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201087 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14229550 | 0.89 | POLB (0.43) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201058 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201136 | 0.86 | HPGD (0.53) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201093 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2HTTHPGDRAB9ANPC1 | |
| SCHEMBL14201075 | 0.85 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTHPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |