Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.72 |
| ▸ | BACE1 | P56817 | 19/20 | 0.64 |
| ▸ | BACE2 | Q9Y5Z0 | 5/20 | 0.54 |
| ▸ | REN | P00797 | 4/20 | 0.51 |
| ▸ | CTSD | P07339 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3456361 | 0.90 | APP (0.75) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13016932 | 0.90 | APP (0.68) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13016523 | 0.88 | APP (0.63) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13016910 | 0.85 | BACE1 (0.69) | APPBACE1BACE2RENCTSD | |
| SCHEMBL14542691 | 0.85 | BACE1 (0.69) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13016954 | 0.84 | APP (0.61) | APPBACE1BACE2RENCTSD | |
| SCHEMBL14542982 | 0.83 | APP (0.60) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13016947 | 0.83 | APP (0.60) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13017069 | 0.83 | APP (0.60) | APPBACE1BACE2RENCTSD | |
| SCHEMBL13017248 | 0.83 | BACE1 (0.69) | APPBACE1BACE2RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038271-A9 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH CORP (US) | 2008-05-08 | — | — | WO | disclosed |
| WO-2007038271-A1 | AMINO-5- [4- (DIFLUOROMETHOXY) PHENYL] -5-PHENYLIMIDAZOLONE COMPOUNDS AS INHIBITORS OF THE BETA-SECRETASE (BACE) | WYETH (US) | 2007-04-05 | — | — | WO | disclosed |