Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | SCN1A | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.39 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14700382 | 0.89 | TSHR (0.46) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL14209896 | 0.86 | MEN1 (0.44) | TSHRTP53KMT2AMEN1NPC1 | |
| SCHEMBL5083377 | 0.84 | TSHR (0.50) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL15801084 | 0.82 | TSHR (0.42) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL14209875 | 0.82 | TSHR (0.42) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL14209885 | 0.81 | TSHR (0.44) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL6154377 | 0.79 | TSHR (0.49) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL14209880 | 0.79 | TSHR (0.45) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL14232641 | 0.79 | TSHR (0.45) | TSHRTP53KMT2AMEN1POLB | |
| SCHEMBL14700381 | 0.78 | TSHR (0.44) | TSHRTP53KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8933269-B2 | Rosuvastatin calcium intermediate and method for preparing the same | PORTON FINE CHEMICALS LTD. (CN) | 2015-01-13 | — | — | US | disclosed |
| US-8933269-B2 | Rosuvastatin calcium intermediate and method for preparing the same | PORTON FINE CHEMICALS LTD. (CN) | 2015-01-13 | — | — | US | disclosed |
| EP-2557084-B1 | ROSUVASTATIN CALCIUM INTERMEDIATE AND PREPARATION METHOD THEREOF | PORTON FINE CHEMICALS LTD (CN) | 2014-06-18 | — | — | EP | disclosed |
| US-20120310000-A1 | ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME | PORTON FINE CHEMICALS LTD. (CN) | 2012-12-06 | — | — | US | disclosed |
| US-20120310000-A1 | ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME | PORTON FINE CHEMICALS LTD. (CN) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120310000-A1 | ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME | ROS1, KCNN2, KCNN4 | TSHR 3934/4885TP53 2159/4885KMT2A 1935/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.