Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 11/20 | 0.36 |
| ▸ | CTSD | P07339 | 7/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1424309 | 1.00 | ABL1 (0.36) | ABL1BACE1CTSDBACE2CYP17A1 | |
| SCHEMBL1420673 | 0.91 | BACE1 (0.39) | ABL1BACE1CTSDBACE2CYP17A1 | |
| SCHEMBL4309373 | 0.89 | ABL1 (0.36) | ABL1BACE1CTSDBACE2REN | |
| SCHEMBL1421083 | 0.86 | SYK (0.37) | ABL1BACE1CTSDBACE2CYP17A1 | |
| SCHEMBL1420814 | 0.84 | BACE1 (0.35) | BACE1CYP17A1BRAFRORC | |
| SCHEMBL7990965 | 0.83 | ABL1 (0.35) | ABL1BACE1CTSDBACE2CYP17A1 | |
| SCHEMBL1421086 | 0.80 | BACE1 (0.46) | BACE1CTSDBACE2REN | |
| SCHEMBL4313717 | 0.78 | BACE1 (0.36) | ABL1BACE1CTSDBACE2REN | |
| SCHEMBL17004575 | 0.78 | BACE1 (0.42) | ABL1BACE1CTSDBACE2CYP17A1 | |
| SCHEMBL17004577 | 0.78 | BACE1 (0.42) | ABL1BACE1CTSDBACE2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297120-A1 | AMINODIHYDROTHIAZINE DERIVATIVES AS BACE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Eli Lilly & Company (US) | 2011-03-23 | — | — | EP | disclosed |